Update on Recurrent Focal Segmental Glomerulosclerosis in Kidney Transplantation
نویسندگان
چکیده
منابع مشابه
Kidney Transplantation in Patients with Focal Segmental Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy primarily caused by podocyte injury that leads to focal adhesions formation between the glomerular tut and the visceral layer of Bowman capsule (1,2). h e global incidence of FSGS has been estimated at 8 cases/million/year, with 40-60% of patients developing end-stage renal disease (ESRD) within 10 to 20 years at er diagnosis (3,4). ...
متن کاملUnsuccessful Treatment with Abatacept in Recurrent Focal Segmental Glomerulosclerosis after Kidney Transplantation
Recurrence of focal segmental glomerulosclerosis (FSGS) after renal transplantation occurs in up to 20-50% of FSGS patients and is associated with inferior allograft survival. Treatment of both primary FSGS as well as recurrent FSGS after transplantation with plasma exchange and immunosuppression is often unsuccessful and remains a major challenge as the disease still leads to end-stage renal d...
متن کاملSuccessful treatment of recurrent focal segmental glomerulosclerosis after kidney transplantation by plasmapheresis and rituximab.
A 22-year-old patient whose primary kidney disease was focal segmental glomerulosclerosis (FSGS) developed severe recurrence of proteinuria (up to 57 g/24 h) immediately after a haploidentic living donor kidney transplantation despite pre-operative plasmapheresis. The immunosuppressive treatment consisted of tacrolimus, mycophenolate mofetil, basiliximab and steroids. He underwent 10 plasmapher...
متن کاملUpdate on the treatment of focal segmental glomerulosclerosis in renal transplantation.
Focal segmental glomerulosclerosis (FSGS) represents one of the most severe glomerular diseases, with frequent progression to end-stage renal disease and a high rate of recurrence in renal allografts (30%-50%). Recurrent FSGS portends a negative outcome, with the hazard ratio of graft failure being two-fold higher then that of other glomerulonephritis. Two patterns of clinical presentations are...
متن کاملRituximab targets podocytes in recurrent focal segmental glomerulosclerosis.
Focal segmental glomerulosclerosis (FSGS) is a glomerular disease characterized by proteinuria, progression to end-stage renal disease, and recurrence of proteinuria after kidney transplantation in about one-third of patients. It has been suggested that rituximab might treat recurrent FSGS through an unknown mechanism. Rituximab not only recognizes CD20 on B lymphocytes, but might also bind sph...
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ژورنال
عنوان ژورنال: Nephron
سال: 2020
ISSN: 1660-8151,2235-3186
DOI: 10.1159/000510748